Allergic Reactions

As with any insulin therapy, injection site reactions may occur and include pain, redness, itching, hives, swelling, bruising, and inflammation. Continuous rotation of the injection site within a given area reduces the risk of developing these reactions. Reactions usually resolve in a few days to a few weeks. On rare occasions, injection site reactions may require discontinuation of NovoLog (NovoRapid). Localized reactions and generalized myalgias have been reported with injected metacresol, an excipient in NovoLog (NovoRapid).

Systemic allergic reactions have not been reported during the clinical development of NovoLog (NovoRapid). Systemic allergic reactions have rarely occurred with NovoLog (NovoRapid) as with other insulin treatments. These reactions may be characterized by a generalized rash (with pruritus), shortness of breath, wheezing, and a drop in blood pressure. Severe cases of generalized allergy, including anaphylactic reaction, may be life-threatening.